Procion Blue HB

Research use only, not for human use.

Procion Blue HB (Reactive Blue 2) is a triazine dye that removes viral particles from plasma protein solutions.

Procion Blue HB (Reactive Blue 2) is a purinergic antagonist.

Reactive Blue 2 is used as an ATP receptor antagonist and induces Ca2+ oscillations in HeLa cells. Reactive Blue 2 enhances a Ca2+ response to histamine that is linked to the PLC cascade. Reactive Blue 2 may activate the PLC cascade in an extracellular Ca2+-dependent manner and induce Ca2+ oscillations. The application of Reactive Blue 2 increases K+ secretion in a dose-dependent manner, and this increase is characterized as a peak followed by a partial relaxation to a steady-state. Reactive Blue 2 has antagonistic activities at P2Y4, and the antagonist potency at P2Y4 paralleled the potency of K+ secretion.The anthraquinone dye reactive blue 2 is found to be a potent inhibitor of a protein kinase isolated and purified from thylakoids. The mode of inhibition is noncompetitive, with a Ki of 8 μM for the membrane-bound kinase, and 6 microM for the purified kinase. The inhibitor does not modify the substrate preference of the endogenous kinase and could be removed from the membrane by washing. Reactive blue 2 selectively inhibits responses mediated via the P2ypurinoceptor, at least within a limited concentration range. In preparations where the tone has been raised with noradrenaline, ATP and 2-methylthio ATP, but not α,β-methylene ATP, produce relaxations of the vessel. These relaxations are inhibited in the presence of reactive blue 2. Reactive blue 2, at concentrations of 0.3-10 μM blocks the ATP-induced oscillation in a concentration-dependent manner.

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Others

Other Targets

Others

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12236-82-7

774.16

C58H40Cl2N14O22S6

>98% (HPLC)

In Vitro:?DMSO : ≥ 110 mg/mL (142.09 mM; )H2O : 10 mg/mL (12.92 mM; Ultrasonic)Ethanol : 1 mg/mL (1.29 mM; Ultrasonic)

Nc1c(cc(Nc2ccc(N=c3[nH]c(Cl)nc(=Nc4cccc(c4)S(O)(=O)=O)[nH]3)c(c2)S(O)(=O)=O)c2C(=O)c3ccccc3C(=O)c12)S(O)(=O)=O

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(-20℃)

With Ice Pack

≥ 2 years